Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime-Avibactam Resistance in Pseudomonas aeruginosa Acute Infection

Dynamic Emergence of Mismatch Repair Deficiency Facilitates Rapid Evolution of Ceftazidime-Avibactam Resistance in Pseudomonas aeruginosa Acute Infection

Antimicrobial resistance in bacteria represents one of the most consequential problems in modern medicine, and its emergence and spread threaten to compromise central advances in the treatment of infectious diseases. Ceftazidime-avibactam (CZA) belongs to a new class of broad-spectrum beta-lactam/be...

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Bibliographic Details
Main Authors: Pavel P. Khil, Augusto Dulanto Chiang, Jonathan Ho, Jung-Ho Youn, Jamie K. Lemon, Juan Gea-Banacloche, Karen M. Frank, Mark Parta, Robert A. Bonomo, John P. Dekker
Format: Article
Language:English
Published: American Society for Microbiology 2019-09-01
Series:mBio
Subjects:
pseudomonas aeruginosa
antimicrobial agents
bacterial evolution
ceftazidime-avibactam
host-pathogen interactions
hypermutator
microbial genomics
mismatch repair
Online Access:https://doi.org/10.1128/mBio.01822-19

Internet

https://doi.org/10.1128/mBio.01822-19

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