Upregulation of microRNA-17-5p contributes to hypoxia-induced proliferation in human pulmonary artery smooth muscle cells through modulation of p21 and PTEN

Upregulation of microRNA-17-5p contributes to hypoxia-induced proliferation in human pulmonary artery smooth muscle cells through modulation of p21 and PTEN

Abstract Background Pulmonary arterial smooth muscle cell (PASMC) proliferation in response to hypoxia plays an important role in the vascular remodelling that occurs in hypoxic pulmonary hypertension. MicroRNAs (miRs) are emerging as important regulators in the progression of pulmonary hypertension...

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Bibliographic Details
Main Authors: Guangjie Liu, Peng Hao, Jie Xu, Liming Wang, Yuchuan Wang, Ruifang Han, Ming Ying, Shuangshuang Sui, Jinghua Liu, Xuan Li
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Respiratory Research
Subjects:
Hypoxia
Pulmonary hypertension
miR-17-5p
PTEN
p21
Online Access:http://link.springer.com/article/10.1186/s12931-018-0902-0

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http://link.springer.com/article/10.1186/s12931-018-0902-0

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