Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit

Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit

Impact of stress on diseases including gastrointestinal failure is well-known, but molecular mechanism is not understood. Here we show underlying molecular mechanism using EAE mice. Under stress conditions, EAE caused severe gastrointestinal failure with high-mortality. Mechanistically, autoreactive...

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Bibliographic Details
Main Authors: Yasunobu Arima, Takuto Ohki, Naoki Nishikawa, Kotaro Higuchi, Mitsutoshi Ota, Yuki Tanaka, Junko Nio-Kobayashi, Mohamed Elfeky, Ryota Sakai, Yuki Mori, Tadafumi Kawamoto, Andrea Stofkova, Yukihiro Sakashita, Yuji Morimoto, Masaki Kuwatani, Toshihiko Iwanaga, Yoshichika Yoshioka, Naoya Sakamoto, Akihiko Yoshimura, Mitsuyoshi Takiguchi, Saburo Sakoda, Marco Prinz, Daisuke Kamimura, Masaaki Murakami
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
brain micro-inflammation
organ function
EAE
multiple sclerosis
neurodegenerative disease
Online Access:https://elifesciences.org/articles/25517

Internet

https://elifesciences.org/articles/25517

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