Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria

Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria

Abstract Background Accurate measurement of anti-malarial drug concentrations in therapeutic efficacy studies is essential to distinguish between inadequate drug exposure and anti-malarial drug resistance, and to inform optimal anti-malarial dosing in key target population groups. Methods A sensitiv...

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Bibliographic Details
Main Authors: Thomas A. Anyorigiya, Sandra Castel, Katya Mauff, Frank Atuguba, Bernhards Ogutu, Abraham Oduro, David Dosoo, Kwaku-Poku Asante, Seth Owusu-Agyei, Alexander Dodoo, Abraham Hodgson, Fred Binka, Lesley J. Workman, Elizabeth N. Allen, Paolo Denti, Lubbe Wiesner, Karen I. Barnes
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Malaria Journal
Subjects:
Amodiaquine
Artesunate
Fixed-dose combination
Pharmacokinetics
P. falciparum malaria
Ghana
Online Access:https://doi.org/10.1186/s12936-020-03553-6

Internet

https://doi.org/10.1186/s12936-020-03553-6

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