Human γδ T Cell Receptor Repertoires in Peripheral Blood Remain Stable Despite Clearance of Persistent Hepatitis C Virus Infection by Direct-Acting Antiviral Drug Therapy

Human γδ T Cell Receptor Repertoires in Peripheral Blood Remain Stable Despite Clearance of Persistent Hepatitis C Virus Infection by Direct-Acting Antiviral Drug Therapy

Human γδ T cells can contribute to clearance of hepatitis C virus (HCV) infection but also mediate liver inflammation. This study aimed to understand the clonal distribution of γδ T cells in peripheral blood of chronic HCV patients and following HCV clearance by interferon-free direct-acting antivir...

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Bibliographic Details
Main Authors: Sarina Ravens, Julia Hengst, Verena Schlapphoff, Katja Deterding, Akshay Dhingra, Christian Schultze-Florey, Christian Koenecke, Markus Cornberg, Heiner Wedemeyer, Immo Prinz
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
γδ T cells
chronic hepatitis C virus
TRG
TRD
next-generation sequencing
direct-acting antivirals
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00510/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00510/full

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