Pharmacological c-Jun NH2-Terminal Kinase (JNK) Pathway Inhibition Reduces Severity of Spinal Muscular Atrophy Disease in Mice

Pharmacological c-Jun NH2-Terminal Kinase (JNK) Pathway Inhibition Reduces Severity of Spinal Muscular Atrophy Disease in Mice

Spinal muscular atrophy (SMA) is a severe neurodegenerative disorder that occurs in early childhood. The disease is caused by the deletion/mutation of the survival motor neuron 1 (SMN1) gene resulting in progressive skeletal muscle atrophy and paralysis, due to the degeneration of spinal motor neuro...

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Bibliographic Details
Main Authors: Roberta Schellino, Marina Boido, Tiziana Borsello, Alessandro Vercelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
motor neuron disease
MAPK
motor endplates
therapy
innervation
muscle
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00308/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00308/full

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