Development of Novel Isoindolone‐Based Compounds against Trypanosoma brucei rhodesiense

Development of Novel Isoindolone‐Based Compounds against Trypanosoma brucei rhodesiense

Abstract This study identified the isoindolone ring as a scaffold for novel agents against Trypanosoma brucei rhodesiense and explored the structure‐activity relationships of various aromatic ring substitutions. The compounds were evaluated in an integrated in vitro screen. Eight compounds exhibited...

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Bibliographic Details
Main Authors: Dr. Daniel G. Silva, Pim‐Bart Feijens, Rik Hendrickx, An Matheeussen, Lucie Grey, Prof. Dr. Guy Caljon, Prof. Dr. Louis Maes, Prof. Dr. Flavio S. Emery, Dr. Anna Junker
Format: Article
Language:English
Published: Wiley-VCH 2021-09-01
Series:ChemistryOpen
Subjects:
anti-infectives
heterocyclic
in vitro
T. b. brucei
T. b. rhodesiense
Online Access:https://doi.org/10.1002/open.202100180

Internet

https://doi.org/10.1002/open.202100180

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