Brain-targeted hypoxia-inducible factor stabilization reduces neonatal hypoxic-ischemic brain injury

Brain-targeted hypoxia-inducible factor stabilization reduces neonatal hypoxic-ischemic brain injury

Hypoxia-inducible factor-1α (HIF1α) is a major regulator of cellular adaptation to hypoxia and oxidative stress, and recent advances of prolyl-4-hydroxylase (P4H) inhibitors have produced powerful tools to stabilize HIF1α for clinical applications. However, whether HIF1α provokes or resists neonatal...

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Bibliographic Details
Main Authors: Chia-Yi Kuan, Hong-Ru Chen, Ning Gao, Yi-Min Kuo, Ching-Wen Chen, Dianer Yang, Melissa M. Kinkaid, Erding Hu, Yu-Yo Sun
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Neurobiology of Disease
Subjects:
Birth asphyxia
Erythropoietin
Hypoxic-ischemic encephalopathy
Intranasal
Prolyl-hydroxylase
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120304757

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http://www.sciencedirect.com/science/article/pii/S0969996120304757

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