Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker

Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker

DnaK/Hsp70 chaperones form oligomers of poorly understood structure and functional significance. Site-specific proteolysis and crosslinking were used to probe the architecture of oligomers formed by the endoplasmic reticulum (ER) Hsp70, BiP. These were found to consist of adjacent protomers engaging...

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Bibliographic Details
Main Authors: Steffen Preissler, Joseph E Chambers, Ana Crespillo-Casado, Edward Avezov, Elena Miranda, Juan Perez, Linda M Hendershot, Heather P Harding, David Ron
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-10-01
Series:eLife
Subjects:
BiP/GRP78
Hsp70
oligomerization
endoplasmic reticulum
Online Access:https://elifesciences.org/articles/08961

Internet

https://elifesciences.org/articles/08961

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