Activation of the NLRP3 Inflammasome Pathway by Prokineticin 2 in Testicular Macrophages of Uropathogenic Escherichia coli- Induced Orchitis

Activation of the NLRP3 Inflammasome Pathway by Prokineticin 2 in Testicular Macrophages of Uropathogenic Escherichia coli- Induced Orchitis

Infections of the reproductive tract are known to contribute to testicular inflammatory impairment, leading to an increase of pro-inflammatory cytokines such as IL-1β, and a decline in sperm quality. Prokineticin 2 (PK2), a secretory protein, is closely associated with the secretion of pro-inflammat...

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Bibliographic Details
Main Authors: Ying Li, Yufang Su, Ting Zhou, Zhiyong Hu, Jiajing Wei, Wei Wang, Chunyan Liu, Huiping Zhang, Kai Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
Prokineticin 2
IL-1β
testicular macrophages
inflammasome
orchitis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01872/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01872/full

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