B-1 cell heterogeneity and the regulation of natural and antigen-induced IgM production
A small subset of B cells, termed B-1 cells, with developmental origins, phenotype and functions that are distinct from those of conventional B cells exist in mice, which contributes the vast majority of spontaneously produced natural IgM. Natural IgM is constitutively produced, even in the absence...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00324/full |