Effect of heparin and related glycosaminoglycan on PDGF-induced lung fibroblast proliferation, chemotactic response and matrix metalloproteinases activity

Fibroblast migration, proliferation, extacellular matrix protein synthesis and degradation are the key events in various biological and pathological processes in pulmonary fibrosis. In addition, biopsy specimens from the lungs of patients with plumomary fibrosis show increased numbers of mast cells...

Full description

Bibliographic Details
Main Authors: Masahiro Sasaki, Masayuki Kashima, Takefumi Ito, Akiko Watanabe, Masaaki Sano, Manabu Kagaya, Takanobu Shioya, Mamoru Miura
Format: Article
Language:English
Published: Hindawi Limited 2000-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1080/096293500411541