Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells

Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells

Genetic analysis has revealed that the dual specificity protein kinase DYRK1A has multiple roles in the development of the central nervous system. Increased DYRK1A gene dosage, such as occurs in Down syndrome, is known to affect neural progenitor cell differentiation, while haploinsufficiency of DYR...

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Bibliographic Details
Main Authors: Stephanie F Bellmaine, Dmitry A Ovchinnikov, David T Manallack, Claire E Cuddy, Andrew G Elefanty, Edouard G Stanley, Ernst J Wolvetang, Spencer J Williams, Martin Pera
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
Homo sapiens
pluripotent
stem cell
Online Access:https://elifesciences.org/articles/24502

Internet

https://elifesciences.org/articles/24502

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