Broad adaptive immune responses to M. tuberculosis antigens precede TST conversion in tuberculosis exposed household contacts in a TB-endemic setting.

Broad adaptive immune responses to M. tuberculosis antigens precede TST conversion in tuberculosis exposed household contacts in a TB-endemic setting.

The identification of Mycobacterium-tuberculosis (Mtb) infected individuals remains a challenge due to an insufficient understanding of immune responses detected with the current diagnostic tests for latent tuberculosis i.e. the tuberculin skin test (TST) or IFN-γ release assays (IGRAs) and an inabi...

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Bibliographic Details
Main Authors: Ulrike K Buchwald, Ifedayo M O Adetifa, Christian Bottomley, Patrick K Owiafe, Simon Donkor, Adama L Bojang, Jayne S Sutherland
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4280211?pdf=render

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http://europepmc.org/articles/PMC4280211?pdf=render

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