Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition

Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition

Microglia, a type of immune cell in the brain, are in a ramified status with branched processes in normal conditions. Upon pathological stimulation, microglia retract their processes and become activated. Searching methods to make the activated microglia return to ramified status would help cope wit...

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Bibliographic Details
Main Authors: Peng Wang, Yaru Zhang, Yu Gong, Rongrong Yang, Zhuo Chen, Wenfeng Hu, Yue Wu, Minhui Gao, Xing Xu, Yibin Qin, Chao Huang
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Neurobiology of Disease
Subjects:
Sodium butyrate
Protein kinase B
Microglia
Small RhoGTPase
Neuroinflammation
Process elongation
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611730284X

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http://www.sciencedirect.com/science/article/pii/S096999611730284X

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