Reduction of Ischemic Damage in NGF-Transgenic Mice: Correlation with Enhancement of Antioxidant Enzyme Activities

Reduction of Ischemic Damage in NGF-Transgenic Mice: Correlation with Enhancement of Antioxidant Enzyme Activities

If permanent focal ischemia is induced by middle cerebral artery occlusion (MCAO), neurons within the infarcted territory die by necrosis and apoptosis (or programmed cell death). We have previously shown, using a mouse strain transgenic (tg) for the nerve growth factor (NGF) gene, that tg mice have...

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Bibliographic Details
Main Authors: Christelle Guégan, Irène Ceballos-Picot, Elisabeth Chevalier, Annie Nicole, Brigitte Onténiente, Brigitte Sola
Format: Article
Language:English
Published: Elsevier 1999-06-01
Series:Neurobiology of Disease
Subjects:
superoxide dismutase
glutathione metabolism
Bcl-2 family
nerve growth factor
transgenic mice
cerebral ischemia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996199902401

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http://www.sciencedirect.com/science/article/pii/S0969996199902401

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