Kororamides, Convolutamines, and Indole Derivatives as Possible Tau and Dual-Specificity Kinase Inhibitors for Alzheimer’s Disease: A Computational Study

Kororamides, Convolutamines, and Indole Derivatives as Possible Tau and Dual-Specificity Kinase Inhibitors for Alzheimer’s Disease: A Computational Study

Alzheimer’s disease (AD) is becoming one of the most disturbing health and socioeconomic problems nowadays, as it is a neurodegenerative pathology with no treatment, which is expected to grow further due to population ageing. Actual treatments for AD produce only a modest amelioration of s...

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Bibliographic Details
Main Authors: Laura Llorach-Pares, Alfons Nonell-Canals, Conxita Avila, Melchor Sanchez-Martinez
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Marine Drugs
Subjects:
meridianins
kororamide A–B
convolutamine I–J
indole scaffold
computer-aided drug design
Alzheimer’s disease
GSK3β
CK1δ
DYRK1A
CLK1
Online Access:http://www.mdpi.com/1660-3397/16/10/386

Internet

http://www.mdpi.com/1660-3397/16/10/386

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