Complexes of Pro-Apoptotic siRNAs and Carbosilane Dendrimers: Formation and Effect on Cancer Cells

Complexes of Pro-Apoptotic siRNAs and Carbosilane Dendrimers: Formation and Effect on Cancer Cells

This paper examines the complexation of anti-cancer small interfering RNAs (siRNAs) by cationic carbosilane dendrimers, and the interaction of the formed complexes with HeLa and HL-60 cancer cells. Stepwise formation of the complexes accompanied by the evolution of their properties has been observed...

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Bibliographic Details
Main Authors: Olga A. Krasheninina, Evgeny K. Apartsin, Elena Fuentes, Aleksandra Szulc, Maksim Ionov, Alya G. Venyaminova, Dzmitry Shcharbin, F. Javier de la Mata, Maria Bryszewska, Rafael Gόmez
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Pharmaceutics
Subjects:
carbosilane
dendrimers
anticancer siRNA
nucleic acids
dendriplexes
complexation
transfection
cytotoxicity
biophysical assays
Online Access:http://www.mdpi.com/1999-4923/11/1/25

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http://www.mdpi.com/1999-4923/11/1/25

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