The impact of Keap1/Nrf2, P38MAPK/NF-κB and Bax/Bcl2/caspase-3 signaling pathways in the protective effects of berberine against methotrexate-induced nephrotoxicity

The impact of Keap1/Nrf2, P38MAPK/NF-κB and Bax/Bcl2/caspase-3 signaling pathways in the protective effects of berberine against methotrexate-induced nephrotoxicity

Berberine (BBR) is a natural compound of plant origin belonging to isoquinoline type of alkaloid. Methotrexate (MTX) is an anti-metabolite used widely for a variety of tumors and autoimmune conditions. Clinical uses of MTX were severely limited by its concomitant renal intoxication. The current stud...

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Bibliographic Details
Main Authors: Emad H.M. Hassanein, Abdel-Gawad S. Shalkami, Marwa M. Khalaf, Wafaa R. Mohamed, Ramadan A.M. Hemeida
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Berberine
Methotrexate
Nephrotoxicity
Keap1/Nrf2
NF-κB/P38MAPK
Bax/Bcl2/caspase-3
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218370483

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http://www.sciencedirect.com/science/article/pii/S0753332218370483

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