Hepatic Fatty Acid Oxidation Restrains Systemic Catabolism during Starvation

The liver is critical for maintaining systemic energy balance during starvation. To understand the role of hepatic fatty acid β-oxidation on this process, we generated mice with a liver-specific knockout of carnitine palmitoyltransferase 2 (Cpt2L−/−), an obligate step in mitochondrial long-chain fat...

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Bibliographic Details
Main Authors: Jieun Lee, Joseph Choi, Susanna Scafidi, Michael J. Wolfgang
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471630660X