Assessment of the Effect of Sorafenib on Omega-6 and Omega-3 Epoxyeicosanoid Formation in Patients with Hepatocellular Carcinoma

Assessment of the Effect of Sorafenib on Omega-6 and Omega-3 Epoxyeicosanoid Formation in Patients with Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is a leading cause of cancer death. The multikinase inhibitor sorafenib is widely used for systemic therapy in advanced HCC. Sorafenib might affect epoxyeicosanoids, as it is also a potent inhibitor of the soluble epoxide hydrolase (sEH), which catalyzes the conversion...

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Bibliographic Details
Main Authors: Can G. Leineweber, Anne Pietzner, Ingrid W. Zhang, Usha B. Blessin, Michael Rothe, Eckart Schott, Nils H. Schebb, Karsten H. Weylandt
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
hepatocellular carcinoma
hcc
soluble epoxide hydrolase
sorafenib
eet
edp
omega-3 fatty acids
n-3 pufa
arachidonic acid
docosahexaenoic acid
Online Access:https://www.mdpi.com/1422-0067/21/5/1875

Internet

https://www.mdpi.com/1422-0067/21/5/1875

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