CPT1A/2-Mediated FAO Enhancement—A Metabolic Target in Radioresistant Breast Cancer

CPT1A/2-Mediated FAO Enhancement—A Metabolic Target in Radioresistant Breast Cancer

Tumor cells, including cancer stem cells (CSCs) resistant to radio- and chemotherapy, must enhance metabolism to meet the extra energy demands to repair and survive such genotoxic conditions. However, such stress-induced adaptive metabolic alterations, especially in cancer cells that survive radioth...

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Bibliographic Details
Main Authors: Shujun Han, Ryan Wei, Xiaodi Zhang, Nian Jiang, Ming Fan, Jie Hunter Huang, Bowen Xie, Lu Zhang, Weili Miao, Ashley Chen-Ping Butler, Matthew A. Coleman, Andrew T. Vaughan, Yinsheng Wang, Hong-Wu Chen, Jiankang Liu, Jian Jian Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Oncology
Subjects:
breast cancer stem cells
CPT1A/CPT2
FAO
metabolism
radioresistance
breast cancer
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01201/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01201/full

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