Bronchopulmonary Dysplasia: Crosstalk Between PPARγ, WNT/β-Catenin and TGF-β Pathways; The Potential Therapeutic Role of PPARγ Agonists

Bronchopulmonary Dysplasia: Crosstalk Between PPARγ, WNT/β-Catenin and TGF-β Pathways; The Potential Therapeutic Role of PPARγ Agonists

Bronchopulmonary dysplasia (BPD) is a serious pulmonary disease which occurs in preterm infants. Mortality remains high due to a lack of effective treatment, despite significant progress in neonatal resuscitation. In BPD, a persistently high level of canonical WNT/β-catenin pathway activity at the c...

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Bibliographic Details
Main Authors: Yves Lecarpentier, Elizabeth Gourrier, Vincent Gobert, Alexandre Vallée
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pediatrics
Subjects:
bronchopulmonary dysplasia
canonical WNT/β-catenin
TGF-β
PPARγ
fibrosis
myofibroblast
Online Access:https://www.frontiersin.org/article/10.3389/fped.2019.00176/full

Internet

https://www.frontiersin.org/article/10.3389/fped.2019.00176/full

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