Anti-Infectives Restore ORKAMBI<sup>®</sup> Rescue of F508del-CFTR Function in Human Bronchial Epithelial Cells Infected with Clinical Strains of <i>P. aeruginosa</i>

Anti-Infectives Restore ORKAMBI<sup>®</sup> Rescue of F508del-CFTR Function in Human Bronchial Epithelial Cells Infected with Clinical Strains of <i>P. aeruginosa</i>

Chronic infection and inflammation are the primary causes of declining lung function in Cystic Fibrosis (CF) patients. ORKAMBI<sup>&#174;</sup> (Lumacaftor-Ivacaftor) is an approved combination therapy for Cystic Fibrosis (CF) patients bearing the most common mutation, F508del, in th...

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Bibliographic Details
Main Authors: Onofrio Laselva, Tracy A. Stone, Christine E. Bear, Charles M. Deber
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Biomolecules
Subjects:
cftr
correctors
antimicrobial peptide
tobramycin
infection
anti-inflammatory
<i>pseudomonas aeruginosa</i>
clinical strains
multidrug resistant bacteria
Online Access:https://www.mdpi.com/2218-273X/10/2/334

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https://www.mdpi.com/2218-273X/10/2/334

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