A Flavonoid-Rich Extract of Mandarin Juice Counteracts 6-OHDA-Induced Oxidative Stress in SH-SY5Y Cells and Modulates Parkinson-Related Genes

A Flavonoid-Rich Extract of Mandarin Juice Counteracts 6-OHDA-Induced Oxidative Stress in SH-SY5Y Cells and Modulates Parkinson-Related Genes

Parkinson’s disease (PD) is a degenerative disorder of the nervous system due to unceasing impairment of dopaminergic neurons situated in the substantia nigra. At present, anti-PD drugs acting on dopamine receptors are mainly symptomatic and have only very limited neuroprotective effects, whereas dr...

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Bibliographic Details
Main Authors: Santa Cirmi, Alessandro Maugeri, Giovanni Enrico Lombardo, Caterina Russo, Laura Musumeci, Sebastiano Gangemi, Gioacchino Calapai, Davide Barreca, Michele Navarra
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Antioxidants
Subjects:
neurodegenerative diseases
Parkinson’s disease
mandarin juice
<i>Citrus reticulata</i>
6-OHDA
neuroprotection
Online Access:https://www.mdpi.com/2076-3921/10/4/539

Internet

https://www.mdpi.com/2076-3921/10/4/539

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