Metabolic engineering of Bacillus amyloliquefaciens for enhanced production of S-adenosylmethionine by coupling of an engineered S-adenosylmethionine pathway and the tricarboxylic acid cycle

Metabolic engineering of Bacillus amyloliquefaciens for enhanced production of S-adenosylmethionine by coupling of an engineered S-adenosylmethionine pathway and the tricarboxylic acid cycle

Abstract Background S-Adenosylmethionine (SAM) is a critical cofactor involved in many biochemical reactions. However, the low fermentation titer of SAM in methionine-free medium hampers commercial-scale production. The SAM synthesis pathway is specially related to the tricarboxylic acid (TCA) cycle...

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Bibliographic Details
Main Authors: Liying Ruan, Lu Li, Dian Zou, Cong Jiang, Zhiyou Wen, Shouwen Chen, Yu Deng, Xuetuan Wei
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Biotechnology for Biofuels
Subjects:
S-Adenosylmethionine
Pathway engineering
Pathway coupling
Bacillus amyloliquefaciens
Online Access:http://link.springer.com/article/10.1186/s13068-019-1554-0

Internet

http://link.springer.com/article/10.1186/s13068-019-1554-0

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