Deciphering the mechanism of Indirubin and its derivatives in the inhibition of Imatinib resistance using a “drug target prediction-gene microarray analysis-protein network construction” strategy

Deciphering the mechanism of Indirubin and its derivatives in the inhibition of Imatinib resistance using a “drug target prediction-gene microarray analysis-protein network construction” strategy

Abstract Background The introduction of imatinib revolutionized the treatment of chronic myeloid leukaemia (CML), substantially extending patient survival. However, imatinib resistance is currently a clinical problem for CML. It is very importantto find a strategy to inhibit imatinib resistance. Met...

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Bibliographic Details
Main Authors: Huayao Li, Lijuan Liu, Jing Zhuang, Cun Liu, Chao Zhou, Jing Yang, Chundi Gao, Gongxi Liu, Changgang Sun
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Complementary and Alternative Medicine
Subjects:
Indirubin
Derivatives
Imatinib resistance
Drug target prediction
Gene microarray analysis
Protein network construction
Online Access:http://link.springer.com/article/10.1186/s12906-019-2471-2

Internet

http://link.springer.com/article/10.1186/s12906-019-2471-2

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