Melatonin promotes oligodendroglial maturation of injured white matter in neonatal rats.

OBJECTIVE:To investigate the effects of melatonin treatment in a rat model of white matter damage (WMD) in the developing brain. Additionally, we aim to delineate the cellular mechanisms of melatonin effect on the oligodendroglial cell lineage. METHODS:A unilateral ligation of the uterine artery in...

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Main Authors: Paul Olivier, Romain H Fontaine, Gauthier Loron, Juliette Van Steenwinckel, Valérie Biran, Véronique Massonneau, Angela Kaindl, Jeremie Dalous, Christiane Charriaut-Marlangue, Marie-Stéphane Aigrot, Julien Pansiot, Catherine Verney, Pierre Gressens, Olivier Baud
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2742165?pdf=render