In Vitro ADME Properties of Two Novel Antimicrobial Peptoid-Based Compounds as Potential Agents against Canine Pyoderma

In Vitro ADME Properties of Two Novel Antimicrobial Peptoid-Based Compounds as Potential Agents against Canine Pyoderma

Antimicrobial peptides (AMPs) hold promise as the next generation of antimicrobial agents, but often suffer from rapid degradation in vivo. Modifying AMPs with non-proteinogenic residues such as peptoids (oligomers of N-alkylglycines) provides the potential to improve stability. We have identified t...

Full description

Bibliographic Details
Main Authors: Ines Greco, Bernard D. Hummel, Jaspreet Vasir, Jeffrey L. Watts, Jason Koch, Johannes E. Hansen, Hanne Mørck Nielsen, Peter Damborg, Paul R. Hansen
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
antimicrobial peptoids
peptidomimetics
in vitro ADME
topical formulation
metabolic stability
Online Access:http://www.mdpi.com/1420-3049/23/3/630

Internet

http://www.mdpi.com/1420-3049/23/3/630

Similar Items