Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS.

Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS.

TDP-43 and FUS are RNA-binding proteins that form cytoplasmic inclusions in some forms of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Moreover, mutations in TDP-43 and FUS are linked to ALS and FTLD. However, it is unknown whether TDP-43 and FUS aggregate and ca...

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Bibliographic Details
Main Authors: Zhihui Sun, Zamia Diaz, Xiaodong Fang, Michael P Hart, Alessandra Chesi, James Shorter, Aaron D Gitler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21541367/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21541367/pdf/?tool=EBI

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