Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization

Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization

KLF4, OCT4, SOX2 and MYC cooperate to reorganize chromatin during somatic cell reprogramming. Here the authors show that KLF4 forms a liquid-like biomolecular condensate that recruits OCT4 and SOX2, and that condensation of the isolated KLF4 DNA binding domain with DNA is enhanced by CpG methylation

Bibliographic Details
Main Authors: Rajesh Sharma, Kyoung-Jae Choi, My Diem Quan, Sonum Sharma, Banumathi Sankaran, Hyekyung Park, Anel LaGrone, Jean J. Kim, Kevin R. MacKenzie, Allan Chris M. Ferreon, Choel Kim, Josephine C. Ferreon
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25761-7

Internet

https://doi.org/10.1038/s41467-021-25761-7

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