Acute Simian Immunodeficiency Virus Infection Triggers Early and Transient Interleukin-7 Production in the Gut, Leading to Enhanced Local Chemokine Expression and Intestinal Immune Cell Homing

Acute Simian Immunodeficiency Virus Infection Triggers Early and Transient Interleukin-7 Production in the Gut, Leading to Enhanced Local Chemokine Expression and Intestinal Immune Cell Homing

The intestinal barrier, one of the first targets of HIV/simian immunodeficiency virus (SIV) is subjected to major physiological changes during acute infection. Having previously shown that pharmaceutical injection of interleukin-7 (IL-7) triggers chemokine expression in many organs leading to massiv...

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Bibliographic Details
Main Authors: Rosalie Ponte, Magali Rancez, Suzanne Figueiredo-Morgado, Jacques Dutrieux, Véronique Fabre-Mersseman, Bénédicte Charmeteau-de-Muylder, Thomas Guilbert, Jean-Pierre Routy, Rémi Cheynier, Anne Couëdel-Courteille
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Immunology
Subjects:
acute HIV/simian immunodeficiency virus infection
non-human primates
Chinese rhesus macaque
interleukin-7
intestinal mucosa
macrophage
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00588/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00588/full

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