Yeast-model-based study identified myosin- and calcium-dependent calmodulin signalling as a potential target for drug intervention in chorea-acanthocytosis

Yeast-model-based study identified myosin- and calcium-dependent calmodulin signalling as a potential target for drug intervention in chorea-acanthocytosis

Chorea-acanthocytosis (ChAc) is a rare neurodegenerative disease associated with mutations in the human VPS13A gene. The mechanism of ChAc pathogenesis is unclear. A simple yeast model was used to investigate the function of the single yeast VSP13 orthologue, Vps13. Vps13, like human VPS13A, is invo...

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Bibliographic Details
Main Authors: Piotr Soczewka, Damian Kolakowski, Iwona Smaczynska-de Rooij, Weronika Rzepnikowska, Kathryn R. Ayscough, Joanna Kaminska, Teresa Zoladek
Format: Article
Language:English
Published: The Company of Biologists 2019-01-01
Series:Disease Models & Mechanisms
Subjects:
Yeast
Chorea-acanthocytosis
Vps13
Myo3
Calcium signalling
Endocytosis
Online Access:http://dmm.biologists.org/content/12/1/dmm036830

Internet

http://dmm.biologists.org/content/12/1/dmm036830

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