Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme

Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme

The glycyl radical enzyme (GRE) superfamily utilizes a glycyl radical cofactor to catalyze difficult chemical reactions in a variety of anaerobic microbial metabolic pathways. Recently, a GRE, trans-4-hydroxy-L-proline (Hyp) dehydratase (HypD), was discovered that catalyzes the dehydration of Hyp to...

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Bibliographic Details
Main Authors: Lindsey RF Backman, Yolanda Y Huang, Mary C Andorfer, Brian Gold, Ronald T Raines, Emily P Balskus, Catherine L Drennan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
glycyl radical enzyme
radical chemistry
C. difficile
gut microbiome
hydroxyproline
Online Access:https://elifesciences.org/articles/51420

Internet

https://elifesciences.org/articles/51420

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