A Structural Overview of RNA-Dependent RNA Polymerases from the Flaviviridae Family

A Structural Overview of RNA-Dependent RNA Polymerases from the Flaviviridae Family

RNA-dependent RNA polymerases (RdRPs) from the Flaviviridae family are representatives of viral polymerases that carry out RNA synthesis through a de novo initiation mechanism. They share a ≈ 600-residue polymerase core that displays a canonical viral RdRP architecture resembling an encircled right...

Full description

Bibliographic Details
Main Authors: Jiqin Wu, Weichi Liu, Peng Gong
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:International Journal of Molecular Sciences
Subjects:
Flaviviridae
RNA-dependent RNA polymerase
catalytic motif
de novo initiation
elongation
in cis regulation
Online Access:http://www.mdpi.com/1422-0067/16/6/12943

Internet

http://www.mdpi.com/1422-0067/16/6/12943

Similar Items