Anhydrous reverse micelle nanoparticles: new strategy to overcome sedimentation instability of peptide-containing pressurized metered-dose inhalers

Anhydrous reverse micelle nanoparticles: new strategy to overcome sedimentation instability of peptide-containing pressurized metered-dose inhalers

The objective of this study was to develop a novel anhydrous reverse micelle nanoparticles (ARM-NPs) system to overcome the sedimentation instability of peptide-containing pressurized metered-dose inhalers (pMDIs). A bottom-up method was utilized to fabricate ARM-NPs. Tertiary butyl alcohol (TBA)/wa...

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Bibliographic Details
Main Authors: Zhengwei Huang, Han Wu, Beibei Yang, Longkai Chen, Ying Huang, Guilan Quan, Chune Zhu, Xing Li, Xin Pan, Chuanbin Wu
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Drug Delivery
Subjects:
pressurized metered dose inhaler
anhydrous reverse micelle nanoparticle
sedimentation instability
steric barrier effect
homogenous particle size
Online Access:http://dx.doi.org/10.1080/10717544.2016.1269850

Internet

http://dx.doi.org/10.1080/10717544.2016.1269850

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