Endogenous CCN5 Participates in Angiotensin II/TGF-β1 Networking of Cardiac Fibrosis in High Angiotensin II-Induced Hypertensive Heart Failure

Endogenous CCN5 Participates in Angiotensin II/TGF-β1 Networking of Cardiac Fibrosis in High Angiotensin II-Induced Hypertensive Heart Failure

Aberrant activation of angiotensin II (Ang II) accelerates hypertensive heart failure (HF); this has drawn worldwide attention. The complex Ang II/transforming growth factor (TGF)-β1 networking consists of central mechanisms underlying pro-fibrotic effects; however, this networking still remains unc...

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Bibliographic Details
Main Authors: Anan Huang, Huihui Li, Chao Zeng, Wanli Chen, Liping Wei, Yue Liu, Xin Qi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
angiotensin II
CCN5
cardiac fibrosis
heart failure
hypertension
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01235/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01235/full

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