Exosomally derived Y RNA fragment alleviates hypertrophic cardiomyopathy in transgenic mice

Exosomally derived Y RNA fragment alleviates hypertrophic cardiomyopathy in transgenic mice

Cardiosphere-derived cell exosomes (CDCexo) and YF1, a CDCexo-derived non-coding RNA, elicit therapeutic bioactivity in models of myocardial infarction and hypertensive hypertrophy. Here we tested the hypothesis that YF1, a 56-nucleotide Y RNA fragment, could alleviate cardiomyocyte hypertrophy, inf...

Full description

Bibliographic Details
Main Authors: Feng Huang, Na Na, Takeshi Ijichi, Xiaokang Wu, Kazutaka Miyamoto, Alessandra Ciullo, My Tran, Liang Li, Ahmed Ibrahim, Eduardo Marbán, Geoffrey de Couto
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
hypertrophic cardiomyopathy
non-coding RNA
Y RNA
macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121001086

Internet

http://www.sciencedirect.com/science/article/pii/S2162253121001086

Similar Items