The Marburg Virus VP24 Protein Interacts with Keap1 to Activate the Cytoprotective Antioxidant Response Pathway

The Marburg Virus VP24 Protein Interacts with Keap1 to Activate the Cytoprotective Antioxidant Response Pathway

Kelch-like ECH-associated protein 1 (Keap1) is a ubiquitin E3 ligase specificity factor that targets transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) for ubiquitination and degradation. Disrupting Keap1-Nrf2 interaction stabilizes Nrf2, resulting in Nrf2 nuclear accumulation,...

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Bibliographic Details
Main Authors: Megan R. Edwards, Britney Johnson, Chad E. Mire, Wei Xu, Reed S. Shabman, Lauren N. Speller, Daisy W. Leung, Thomas W. Geisbert, Gaya K. Amarasinghe, Christopher F. Basler
Format: Article
Language:English
Published: Elsevier 2014-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714000771

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http://www.sciencedirect.com/science/article/pii/S2211124714000771

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