Menthyl esterification allows chiral resolution for the synthesis of artificial glutamate analogs

Menthyl esterification allows chiral resolution for the synthesis of artificial glutamate analogs

Herein, we report the enantiospecific synthesis of two artificial glutamate analogs designed based on IKM-159, an antagonist selective to the AMPA-type ionotropic glutamate receptor. The synthesis features the chiral resolution of the carboxylic acid intermediate by the esterification with ʟ-menthol...

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Bibliographic Details
Main Authors: Kenji Morokuma, Shuntaro Tsukamoto, Kyosuke Mori, Kei Miyako, Ryuichi Sakai, Raku Irie, Masato Oikawa
Format: Article
Language:English
Published: Beilstein-Institut 2021-02-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
chiral resolution
configurational analysis
glutamate
metathesis
neuroactivity
Online Access:https://doi.org/10.3762/bjoc.17.48

Internet

https://doi.org/10.3762/bjoc.17.48

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