Design and Discovery of Quinazoline- and Thiourea-Containing Sorafenib Analogs as EGFR and VEGFR-2 Dual TK Inhibitors

Design and Discovery of Quinazoline- and Thiourea-Containing Sorafenib Analogs as EGFR and VEGFR-2 Dual TK Inhibitors

Both EGFR and VEGFR-2 play a critical role in tumor growth, angiogenesis and metastasis, and targeting EGFR and VEGFR-2 simultaneously represents a promising approach to cancer treatment. In this work, a series of novel quinazoline- and thiourea-containing sorafenib analogs (10a–v) were designed and...

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Bibliographic Details
Main Authors: Shaofeng Sun, Jingwen Zhang, Ningning Wang, Xiangkai Kong, Fenghua Fu, Hongbo Wang, Jianwen Yao
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Molecules
Subjects:
quinazoline
thiourea
sorafenib
TK inhibitor
molecular docking
Online Access:https://www.mdpi.com/1420-3049/23/1/24

Internet

https://www.mdpi.com/1420-3049/23/1/24

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