Exogenous Gonadotrophin Stimulation Induces Partial Maturation of Human Sertoli Cells in a Testicular Xenotransplantation Model for Fertility Preservation

Exogenous Gonadotrophin Stimulation Induces Partial Maturation of Human Sertoli Cells in a Testicular Xenotransplantation Model for Fertility Preservation

The future fertility of prepubertal boys with cancer may be irreversibly compromised by chemotherapy and/or radiotherapy. Successful spermatogenesis has not been achieved following the xenotransplantation of prepubertal human testis tissue, which is likely due to the failure of somatic cell maturati...

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Bibliographic Details
Main Authors: Marsida Hutka, Lee B. Smith, Ellen Goossens, W. Hamish B. Wallace, Jan-Bernd Stukenborg, Rod T. Mitchell
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Journal of Clinical Medicine
Subjects:
sertoli cell
leydig cell
steroidogenesis
hcg
human fetal testis
xenotransplantation
fertility preservation
oncofertility
Online Access:https://www.mdpi.com/2077-0383/9/1/266

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https://www.mdpi.com/2077-0383/9/1/266

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