Mechanisms of DNA Damage Tolerance: Post-Translational Regulation of PCNA

Mechanisms of DNA Damage Tolerance: Post-Translational Regulation of PCNA

DNA damage is a constant source of stress challenging genomic integrity. To ensure faithful duplication of our genomes, mechanisms have evolved to deal with damage encountered during replication. One such mechanism is referred to as DNA damage tolerance (DDT). DDT allows for replication to continue...

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Bibliographic Details
Main Authors: Wendy Leung, Ryan M. Baxley, George-Lucian Moldovan, Anja-Katrin Bielinsky
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Genes
Subjects:
PCNA
DNA damage tolerance
translesion synthesis
template switching
ubiquitination
replication stress
Online Access:http://www.mdpi.com/2073-4425/10/1/10

Internet

http://www.mdpi.com/2073-4425/10/1/10

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