Tumoral BRD4 expression in lymph node-negative breast cancer: association with T-bet+ tumor-infiltrating lymphocytes and disease-free survival

Tumoral BRD4 expression in lymph node-negative breast cancer: association with T-bet+ tumor-infiltrating lymphocytes and disease-free survival

Abstract Background We previously observed that T-bet+ tumor-infiltrating T lymphocytes (T-bet+ TILs) in primary breast tumors were associated with adverse clinicopathological features, yet favorable clinical outcome. We identified BRD4 (Bromodomain-Containing Protein 4), a member of the  Bromodomai...

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Bibliographic Details
Main Authors: Minji Lee, Farnoosh Tayyari, Dushanthi Pinnaduwage, Jane Bayani, John M. S. Bartlett, Anna Marie Mulligan, Shelley B. Bull, Irene L. Andrulis
Format: Article
Language:English
Published: BMC 2018-07-01
Series:BMC Cancer
Subjects:
Breast cancer
BRD4
Inflammation
TILs
Lymphocytic infiltration
T-bet
Online Access:http://link.springer.com/article/10.1186/s12885-018-4653-6

Internet

http://link.springer.com/article/10.1186/s12885-018-4653-6

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