Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells

Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells

Sirtuin 6 (SIRT6), a member of sirtuin family (SIRT1-7), regulates a variety of cellular processes involved in aging, metabolism, and cancer. Dysregulation of SIRT6 is widely observed in different breast cancer subtypes; however, the role and function of SIRT6 in cancer development remain largely un...

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Bibliographic Details
Main Authors: Jonna Tenhunen, Tomáš Kučera, Marjo Huovinen, Jenni Küblbeck, Egils Bisenieks, Brigita Vigante, Zaiga Ogle, Gunars Duburs, Martin Doležal, Ruin Moaddel, Maija Lahtela-Kakkonen, Minna Rahnasto-Rilla
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Activator
Breast cancer
Inhibitor
Sirtuin 6
Virtual screening
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221002377

Internet

http://www.sciencedirect.com/science/article/pii/S0753332221002377

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