Pharmacokinetics and Toxicity Evaluation of a PLGA and Chitosan-Based Micro-Implant for Sustained Release of Methotrexate in Rabbit Vitreous

Pharmacokinetics and Toxicity Evaluation of a PLGA and Chitosan-Based Micro-Implant for Sustained Release of Methotrexate in Rabbit Vitreous

The present research investigates the pharmacokinetics and toxicity of a chitosan (CS) and poly(lactic-co-glycolic) acid (PLGA)-based methotrexate (MTX) intravitreal micro-implant in normal rabbit eyes. PLGA and CS-based micro-implants containing 400 µg of MTX were surgically inserted in the vitreou...

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Bibliographic Details
Main Authors: Soumyarwit Manna, Anna M. Donnell, Rafaela Q. Caixeta Faraj, Blanca I. Riemann, Christopher D. Riemann, James J. Augsburger, Zelia M. Correa, Rupak K. Banerjee
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceutics
Subjects:
methotrexate
chitosan
PLA/PLGA
sustained release
micro-implant
animal model
Online Access:https://www.mdpi.com/1999-4923/13/8/1227

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https://www.mdpi.com/1999-4923/13/8/1227

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