Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments

Niemann-Pick type C (NPC) disease is characterized by an accumulation of cholesterol and other lipids in the lysosomal compartment. In this report, we use subcellular fractionation and microscopy to determine the localization of the murine Niemann-Pick C1 (NPC1) protein. Fractionation of mouse liver...

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Bibliographic Details
Main Authors: William S. Garver, Randall A. Heidenreich, Robert P. Erickson, Mitchell A. Thomas, Jean M. Wilson
Format: Article
Published: Elsevier 2000-05-01
Series:Journal of Lipid Research
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520323762