A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome

A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome

Neuromuscular junction is a synapse between motoneurons and skeletal muscles, where acetylcholine receptors (AChRs) are concentrated to control muscle contraction. Studies of this synapse have contributed to our understanding of synapse assembly and pathological mechanisms of neuromuscular disorders...

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Bibliographic Details
Main Authors: Guanglin Xing, Hongyang Jing, Lei Zhang, Yu Cao, Lei Li, Kai Zhao, Zhaoqi Dong, Wenbing Chen, Hongsheng Wang, Rangjuan Cao, Wen-Cheng Xiong, Lin Mei
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
neuromuscular junction
congenital myasthenic syndrome
acetylcholine receptor
Rapsyn
Online Access:https://elifesciences.org/articles/49180

Internet

https://elifesciences.org/articles/49180

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