Anticancer Properties of the Antipsychotic Drug Chlorpromazine and Its Synergism With Temozolomide in Restraining Human Glioblastoma Proliferation In Vitro

Anticancer Properties of the Antipsychotic Drug Chlorpromazine and Its Synergism With Temozolomide in Restraining Human Glioblastoma Proliferation In Vitro

The extremely poor prognosis of patients affected by glioblastoma (GBM, grade IV glioma) prompts the search for new and more effective therapies. In this regard, drug repurposing or repositioning can represent a safe, swift, and inexpensive way to bring novel pharmacological approaches from bench to...

Full description

Bibliographic Details
Main Authors: Silvia Matteoni, Paola Matarrese, Barbara Ascione, Mariachiara Buccarelli, Lucia Ricci-Vitiani, Roberto Pallini, Veronica Villani, Andrea Pace, Marco G. Paggi, Claudia Abbruzzese
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
glioblastoma
antipsychotic drugs (APDs)
drug repurposing and repositioning
cancer stem cells (CSC)
neurospheres
drug synergism
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.635472/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.635472/full

Similar Items