The Kallikrein-Kinin-System in Experimental Chagas Disease: A Paradigm to Investigate the Impact of Inflammatory Edema on GPCR-mediated pathways of Host Cell Invasion by Trypanosoma cruzi

The Kallikrein-Kinin-System in Experimental Chagas Disease: A Paradigm to Investigate the Impact of Inflammatory Edema on GPCR-mediated pathways of Host Cell Invasion by Trypanosoma cruzi

Chronic chagasic myocarditis (CCM) depends on Trypanosoma cruzi persistence in the myocardium. Studies of the proteolytic mechanisms governing host/parasite balance in peripheral sites of T. cruzi infection revealed that tissue culture trypomastigotes (TCTs) elicit inflammatory edema and stimulate p...

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Bibliographic Details
Main Authors: Julio eScharfstein, Daniele eAndrade, Erik eSvensjö, Ana Carolina eOliveira, Clarissa Rodrigues Nascimento
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-01-01
Series:Frontiers in Immunology
Subjects:
Bradykinin
Endothelins
Trypanosoma cruzi
GPCRs
cardiomyopathy
Proteases
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00396/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00396/full

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